apalutamide will lessen the extent or effect of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a solid CYP2C19 inducer, with medicines which have been CYP2C19 substrates may end up in lower publicity to those prescription drugs.fluvoxamine will enhance the degree or influence o